Laure Teysset and Andana Barios

Created in October 21, 2026

2026

Laure Teysset
Transgenerational Epigenetics and small RNA Biology (TErBio) Institut de Biologie Paris-Seine (IBPS), Development Adaptation and Aging (Dev2A) Sorbonne Université, CNRS UMR8263 and INSERM U1345

Title:
TBC

Abstract:
TBC



Andana Barios
Postdoctoral Researcher in Hervé Vaucheret’s team (Epigénétique et petits ARNs) Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin for Plant Sciences

Title:
The lncRNA BAMBOO decoys NF-YA2 transcription factor from the promoter of its root-specific targets in Arabidopsis Abstract:
Plant developmental plasticity emerges from transcriptional reprogramming in response to environmental shifts, which largely depends on the activity of transcription factors (TFs). In Arabidopsis thaliana, CCAAT-binding TFs NF-YA2 and NF-YA10 (Nuclear Factor-Y A2 and A10) are post-transcriptionally regulated by microRNAs, participating in a regulatory hub controlling root architecture. Here, RNA-seq and ChIP-seq approaches served to identify NF-YA2 direct target genes involved in lateral root (LR) development, water deprivation and hormone pathways. Furthermore, we searched for NF-YA2 potential RNA partners by using RIP-seq and identified a long noncoding RNA (lncRNA) named BAMBOO after its counterpart PANDA, which interacts with mammalian NF-YA. BAMBOO is dynamically regulated during LR development and bamboomutant plants exhibit a NF-YA2-related root developmental phenotype. bamboo plants share half of its deregulated genes with the NF-YA2 regulome. In vivo, in vitro and in silico assays indicated that NF-YA2 - BAMBOO interaction depends on the DNA-binding domain and RNA sequence. When overexpressed, the lncRNA BAMBOO disturbed NF-YA2 binding to its target promoters suggesting an RNA-based competition of target recognition by NF-YA2 in chromatin. Hence, the study of lncRNAs at the organism level underscores their capacity to intricately modulate TF activity throughout targeted developmental processes, thereby fine-tuning regulatory networks.